PE-22-28 10mg — High-Purity TREK-1 Channel Research Peptide
PE-22-28 is a highly refined synthetic derivative of spadin, engineered for precision in neurological research. Designed for researchers investigating the TREK-1 potassium channel, this peptide offers enhanced metabolic stability and bioavailability compared to full-length spadin. Whether you are studying neurogenesis, neuroprotection, or the complexities of the central nervous system, PE-22-28 provides the potency and purity required for rigorous laboratory standards.
Specifications
| Amino Acid Sequence | GVSWGLR |
| Molecular Formula | C₃₅H₅₅N₁₁O₉ |
| Molecular Weight | 773.89 g/mol |
| Quantity per Vial | 10 mg |
| Physical Form | Lyophilized powder |
| Purity Assay | 99% |
| Aqueous Solubility | Approximately 2 mg/mL in deionized water |
| Recommended Storage | −20°C (short-term); −80°C (long-term) |
| CAS Registry Number | 18019 fear 1959-12-5 |
| Principal Research Application | TREK-1 channel antagonism; neurogenesis studies; neuroprotection; CNS research |
Description and Research Mechanism
PE-22-28 is a specialized tool for investigating the TREK-1 (TWIK-related potassium) channel, a two-pore potassium channel vital to the nervous economy. This peptide acts as a potent antagonist, focused on the specific amino acid sequence (22 through 28) of the parent spadin molecule. By blocking the TREK-1 channel, PE-22-28 increases neuronal excitability, making it a vital instrument for studying the pathways involved in memory, mood, and emotional regulation.
Beyond its neurological applications, PE-22-28 has demonstrated remarkable potential in studies involving hippocampal neurogenesis. Research indicates that the peptide can stimulate the production of new neurons by influencing the upregulation of Brain-Derived Neurotrophic Factor (BDNF) and CREB phosphorylation. Furthermore, its interaction with muscular mechanoreceptors makes it a candidate of interest for research into muscle physiology and contractility.
This 99% purity, pharmaceutical-grade powder is optimized for stability. Its solubility in deionized water facilitates efficient experimental preparation, ensuring that your research remains consistent and reproducible.
FAQ
What is the primary use for PE-22-28?
PE-22-28 is primarily used in laboratory settings to study TREK-1 channel antagonism, neuroprotection, and the induction of neurogenesis within the hippocampus.
How should PE-22-28 be stored?
For long-term stability, it is recommended to store the lyophilized powder at −80°C. Short-term storage can be maintained at −20°C.
What is the purity of this product?
This product is manufactured to a high standard of excellence, featuring a 99% purity assay as verified by rigorous testing.
Is PE-22-28 soluble in water?
The peptide exhibits a solubility of approximately 2 mg/mL in deionized water, allowing for easy preparation for aqueous-based experiments.