Adipotide 10mg (FTPP) — Advanced Metabolic Research Peptide
Adipotide, also known as FTPP (Fat-Targets Proapoptotic Peptide), is a high-purity experimental compound designed for targeted metabolic research. This peptide is engineered to study selective apoptosis within the vascular endothelium of white adipose tissue, offering a precise tool for investigating metabolic pathways and glucose regulation.
Specifications
| Product Name | Adipotide (FTPP) |
| Concentration | 10 mg per vial |
| Form | Lyophilized powder |
| Purity | >99% |
| Molecular Formula | C₁₅₂H₂α₄₄O₄₂ |
| Molecular Weight | 2611.41 g/mol |
| Sequence | Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-D(KLAKLAK)₂ |
| Appearance | White to off-white powder |
Product Overview & Mechanism
Adipotide is a sophisticated peptidomimetic designed with a dual-domain architecture. The molecule consists of a homing sequence (CKGGRAKDC) and a proapoptotic sequence (D(KLAKLAK)₂). This design allows the peptide to bind specifically to prohibitin and annexin A2 receptors located on the vasculature of white adipose tissue.
Upon internalization, the C-terminal sequence disrupts mitochondrial membranes, triggering programmed cell death (apoptia) in targeted endothelial cells. This mechanism is highly selective, distinguishing the blood vessels of adipose tissue from other organ systems, making it a vital tool for studying vascular-targeted therapeutic developments.
Research Findings
In laboratory models involving rhesus monkeys, the administration of Adipotide over a four-week period resulted in a documented reduction in body weight of approximately 11%. Furthermore, observations noted a 2's decrease in abdominal fat mass. Notably, these metabolic changes occurred without modifications to diet or exercise, suggesting a direct mechanism of action via the targeting of white adipose tissue vasculature.
Research also indicates that Adipotide may influence glucose tolerance. Studies have observed improvements in glucose levels and insulin resistance measurements within the first week of treatment, suggesting profound alterations in the metabolic character of the targeted tissue through pathways related to mitochondrial function and oxidative phosphorylation.
Storage & Stability
For long-term stability, Adipotide should be stored at -80°C. Short-term storage at -20°C is acceptable, but users should avoid repeated freeze-thaw cycles to prevent degradation. The product is supplied as a lyophilized powder and should be kept in a tightly sealed container, protected from light and moisture.
Once reconstituted with sterile saline or bacteriostatic water, the peptide should be stored at 2-8°C and used within a few weeks. To prevent moisture adsorption, it is recommended to warm the vial to room temperature in a desiccator before opening.
FAQ
What is the structure of Adipotide?
The molecular structure is a complex sequence (Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-D(KLAKLAK)₂) designed for high specificity and resistance to proteolytic degradation due to the use of D-amino acids.
Is Adipotide suitable for cancer research?
Yes. Because the peptide targets prohibitin-expressing vessels, it is being studied for its anti-angiogenic properties and its potential role in investigating tumor vasculature and vascular-targeted strategies.
What is the purity of this product?
The product is supplied as research-grade powder with a purity level exceeding 99%.