Ultima-PE-22-28 10mg
- Brand: Ultima Pharma
- Product Code: Ultima-PE-22-28 10mg
- Availability: In Stock
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$100.00
PE-22-28 10mg | Ultima Pharmaceuticals | High-Purity Research Peptide
Enhance your neurological research with PE-22-28, a refined synthetic derivative of Spadin. This high-purity peptide is designed for precision studies involving the TREK-1 channel, offering improved metabolic stability and bioavailability for investigating neurogenesis and neuroprotection.
Specifications
| Specification | Value |
| Amino Acid Sequence | GVSWGLR |
| Molecular Formula | C₃₅H₅₅N₁₁O₉ |
| Molecular Weight | 773.89 g/mol |
| Quantity per Vial | 10 mg |
| Physical Form | Lyophilized powder |
| Purity Assay | 99% |
| Aqueous Solubility | Approximately 2 mg/mL in deionized water |
| Recommended Storage | −20°C (short-term); −80°C (long-term) |
| CAS Registry Number | 1801959-12-5 |
| Principal Research Application | TREK-1 channel antagonism; neurogenesis studies; neuroprotection; CNS research |
Description & Research Applications
PE-22-28 is a potent, selective antagonist of the TREK-1 (a two-pore potassium channel). This synthetic peptide is a condensed seven-amino acid sequence derived from the active core of Spadin. This design offers a more efficient and stable molecule for laboratory use, specifically targeting the TREK-1 channel, which is widely distributed throughout the central and peripheral nervous systems.
In laboratory settings, PE-22-28 has been utilized to study the mechanisms of neurogenesis and neuroprotection. Research indicates that this peptide can influence hippocampal activity, making it an essential tool for investigating the molecular pathways related to memory, mood, and even muscular physiology through its interaction with mechanosensors.
This product is supplied as a 99% purity lyophilized powder. Its readiness for aqueous dissolution (up to 2 mg/mL) ensures ease of preparation for experimental protocols. Whether investigating the impact of TREK-1 on cellular excitability or its role in more complex neurological models, PE-22-28 provides the reliability required for professional scientific inquiry.
FAQ
What is the primary function of PE-22-28?
PE-22-28 acts as a selective antagonist for the TREK-1 potassium channel, making it a vital tool for researchers studying neurogenesis and the regulation of cellular excitability.
How does this peptide compare to full-length Spadin?
As a refined derivative, PE-22-28 is more condensed and offers improved metabolic stability and bioavailability compared to the parent Spadin molecule, without losing its functional potency.
What are the storage recommendations?
To maintain maximum stability, it is recommended to store this peptide at -80°C for long-term use. Short-term storage can be maintained at -20°C.
What is the purity level?
This product is manufactured to a pharmaceutical-grade standard with a documented purity of 99%.