Adipotide (FTPP) 5mg - Ultima Pharma Research Grade Peptide

Adipotide, also known as FTPP (Fat-Targeted Proapoptotic Peptide), is a highly specialized compound engineered for advanced metabolic research. This peptide is designed to target the vascular endothelium of white adipose tissue, offering unique insights into metabolic studies and glucose regulation. Whether you are conducting laboratory analysis or exploring its potential in metabolic pathways, this high-purity lyophilized powder provides the precision required for professional research.

Specifications

Description & Mechanism of Action

Adipotide is a sophisticated peptidomimetic designed to induce selective apoptosis within the vascular endothelium of white adipose tissue. Its unique molecular architecture consists of two functional domains: a homing sequence (CKGGRAKDC) and a proapoptotic sequence (D(KLAKL 2)).

The targeting mechanism works through a ligand-directed process. The N-terminal sequence binds specifically to prohibitin and annexin A2 receptors located on the blood vessels of adipose tissue. Upon internalization, the C-terminal sequence disrupts mitochondrial membranes, triggering programmed cell death in the targeted endothelial cells. This precision allows for the study of metabolic shifts and weight reduction without altering diet or exercise protocols, as evidenced in rhesus monkey studies where reductions in adipose mass were observed through targeted vascular disruption.

Furthermore, research suggests that Adipotide may influence glucose tolerance and insulin sensitivity. In studies, improvements in glucose levels were noted within days, suggesting its potential utility in investigating pathways related to mitochondrial function and metabolic' disposition.

Research Features

• Selective Vascular Targeting: Demonstrates specific affinity for prohibitin-expressing endothelial cells in white adipose tissue.
• Dual-Domain Architecture: Combones a targeting sequence with a proapoptotic domain for bifunctional research utility.
• Metabolic Research Applications: Facilitates the study of glucose tolerance and insulin sensitivity.
• Anti-Angiogenic Potential: Useful for studying vascular disruption and tumor vasculature.
• High Purity: Supplied as a research-grade lyophilized powder with >9 9% purity.

Storage & Handling Instructions

For long-term stability, Adipotide should be stored at -80°C. For short-term use (up to two months), refrigeration at -20°C is acceptable. It is vital to protect the vial from light and moisture. As peptides are hygroscopic, we recommend warming the vial to room temperature in a desiccator before opening to prevent moisture adsorption. Once reconstituted with sterile saline or bacteriostatic water, the solution should be stored at 2-8°C and used within a few weeks.

FAQ

What is Adipotide (FTPP)?
Adipotide is an experimental peptide used in research to study the reduction of white adipose tissue through the targeting of specific proteins like prohibitin within adipose vasculature.

How should this product be stored?
Lyophilized powder should be kept in a freezer at -20°C for short-term or -80°C for long-term storage. Avoid repeated freeze-thaw cycles to prevent degradation.

What is the purity of the product?
This product is manufactured to research-grade standards, offering a purity level of greater than 99%.